Enyel De Los Santos is a Dominican right-handed pitcher for the Houston Astros, born December 25, 1995, in San Pedro de Macorís. This tag page compiles news, game reports, and updates from across his MLB journey, covering stints with the Philadelphia Phillies, Pittsburgh Pirates, Cleveland Guardians, San Diego Padres, New York Yankees, Chicago White Sox, and Atlanta Braves. Coverage includes his 2018 MLB debut win, the immaculate inning he pitched for Cleveland against Tampa Bay on September 27, 2022, and his August 16, 2025, two-pitch, three-out inning with Houston, recognized as the only such inning in major league history.
